It has been tested on Windows ME in the past, and worked, but since I don't want that perticular Windows version anywhere near my harddrive, it's not tested on a regular basis.
Windows 98 and Windows Me will not be supported by future versions of Pelles C, but it would be nice to get v4.50 working on your Windows Me. However, I need more information to do something (anything from screenshots to additional info). I don't even know if it's just your copy, or a general problem with Windows Me...